Similac Alimentum with 2'-FL HMO Hypoallergenic Infant Formula Powder | 12.1 oz

When your baby has been crying inconsolably after every feeding and nothing has worked, cow's milk protein allergy is often the answer — and Similac Alimentum® with 2'-FL HMO is the upgrade that changes everything. It's the first and only hypoallergenic formula that pairs extensively hydrolyzed casein protein with a 2'-FL Human Milk Oligosaccharide — managing cow's milk allergy colic in most infants within 24 hours while simultaneously nourishing the immune system. More protection. Faster relief. One formula.

Key Features & Benefits

• First & Only Hypoallergenic Formula with 2'-FL HMO: The addition of 2'-FL Human Milk Oligosaccharide — a prebiotic found in breast milk — makes this the most advanced hypoallergenic formula in the Similac lineup.
• Clinically Proven Colic Relief in 24 Hours: Backed by clinical evidence showing significant reduction in colic symptoms due to protein sensitivity within 24 hours of switching.
• Extensively Hydrolyzed Casein Protein: Cow's milk proteins broken into very small fragments clinically unlikely to trigger an immune response — appropriate for moderate-to-severe cow's milk protein allergy.
• HMO for Immune System Development: The 2'-FL prebiotic feeds beneficial gut bacteria and helps train the developing immune system — addressing the root cause of allergy-prone infant gut health.
• Iron-Fortified with DHA & ARA: Complete developmental nutrition is maintained — iron for cognitive health, DHA for brain development, ARA for visual acuity.
• 2-Pack & 6-Pack Options: Stock up and save for long-term allergy management without the stress of running low.

Technical Specs

• Age Range: 0–12 months
• Can Size: 12.1 oz powder
• Protein Type: Extensively hydrolyzed casein (casein hydrolysate)
• HMO: 2'-FL Human Milk Oligosaccharide
• Iron: Fortified
• Key Nutrients: DHA, ARA, 2'-FL HMO, vitamins & minerals
• Manufacturer: Abbott / Similac
• Available Quantities: 2-pack ($69.99) | 6-pack case ($179.99)

What is the difference between Similac Alimentum with HMO and the original Similac Alimentum?

The original Similac Alimentum uses the same extensively hydrolyzed casein base but does not contain the 2'-FL HMO. The newer HMO version adds an immune-supporting prebiotic found in breast milk — a meaningful upgrade if your baby was doing well on the original version.

Is Similac Alimentum with HMO the same as Enfamil Nutramigen?

Both are extensively hydrolyzed hypoallergenic formulas for cow's milk protein allergy, but Alimentum uses hydrolyzed casein with 2'-FL HMO, while Nutramigen uses hydrolyzed casein with LGG probiotic. Some infants tolerate one better than the other — if your baby fails one, the other is the logical next clinical step.

Does Similac Alimentum with HMO help with eczema related to cow's milk allergy?

Yes, in many cases. Eczema in infants is frequently linked to cow's milk protein allergy. Switching to Similac Alimentum can help reduce the allergic trigger driving eczema flares, with clinical improvement in skin symptoms often following gut symptom improvement within 2–4 weeks.

You May Also Consider

• Similac Alimentum RTF with HMO — The same formula pre-mixed and ready to pour — zero prep, perfect for newborns and on-the-go feeding.
• Enfamil Nutramigen with LGG — The leading alternative hypoallergenic powder formula with LGG probiotic for accelerated cow's milk tolerance development.
• Neocate Syneo Infant — The next clinical step if extensively hydrolyzed formulas don't fully resolve allergic symptoms — 100% amino acid elemental with pre + probiotics.